- Adults: 1-2 tablets 3-4 times daily.
- Children (6-12 years): 1 tablet 3-4 times daily.
Contraindications:
Paracetamol is contraindicated in patients with severe renal function impairment and hepatic diseases (e.g., Viral Hepatitis).
Precautions:
Paracetamol should be given with care to patients with impaired kidney or liver function or those taking other drugs that affect the liver.
Side Effects:
Side effects of paracetamol are usually mild. Hematological reactions like thrombocytopenia, leukopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Pancreatitis, skin rashes, and allergic reactions occur occasionally.
Use in Pregnancy & Lactation:
Pregnancy Category A. Experimental studies in animals and cohort studies in humans indicate no detectable increase in congenital malformations associated with paracetamol use during pregnancy.
Drug Interactions:
Substances that induce or regulate hepatic cytochrome enzyme CYP2E1 may alter the metabolism of acetaminophen, increasing its hepatotoxic potential. Chronic oral acetaminophen use (4,000 mg/day) can increase INR in patients stabilized on sodium warfarin.
Overdose:
Symptoms of paracetamol overdose in the first 24 hours include pallor, nausea, vomiting, anorexia, and abdominal pain. Liver damage may become apparent 12 to 40 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur.
Storage:
Keep below 30° C, protect from light & moisture. Keep out of the reach of children.
Commercial Pack:
Windol 500 Tablet: Each box contains 20x10's tablets in blister strip.
